Feeling stuck, sluggish, or not like yourself? For many, the journey to better health starts with frustration—whether it’s low energy, weight gain, or simply feeling “off.” At Defy of Indiana, we believe in personalized solutions that make real, lasting change. Two of our patients share their inspiring stories of wellness, transformation, and how their lives were improved through our program!

Q: How were you feeling before starting your wellness journey?

Amy: At 46, I was over 100 pounds overweight, exhausted, and grouchy. Sleep was nonexistent, I had no energy, and I didn’t recognize myself physically or mentally. My weight and lack of motivation left me in a hopeless cycle, feeling stuck in a version of myself I couldn’t escape.

Mitch: Before Defy, I felt sore, sluggish, and weighed down—both physically and mentally. I was dealing with brain fog, joint pain, and ringing in my ears. I knew my long-term health was suffering, but I just chalked it up to aging.

Q: Did you seek help from your doctors?

Amy: I went to my primary care doctor and OB/GYN, begging for help. Their responses? “It’s just part of menopause,” or “Eat less, move more.” Those suggestions felt impossible when I didn’t even have the energy to function, let alone exercise or overhaul my diet.

Mitch: I didn’t seek help from doctors. I just accepted the way I felt as “normal” and only went to the doctor when something serious came up.

Q: What inspired you to try something different?

Amy: A longtime dental patient told me about her incredible results with hormone balancing and peptides. Her energy and confidence were undeniable, and she encouraged me to investigate functional medicine. That conversation changed everything.

Mitch: My friend, and Defy of Indiana’s founder, Dr. Amy Marckese inspired me. Over a year, I saw her energy, confidence, and fitness completely evolve. I watched her life transform through the changes she ma

Q: What changes did you notice after starting BHRT and peptides?

Amy: The changes came quickly. My mood improved, my energy skyrocketed, and my libido returned. I began walking more and noticed less stress eating. Peptides helped suppress my appetite and build muscle, and I lost over 100 pounds in a little more than a year. It was like turning back the clock 15 years.

Mitch: Initially the changes that I felt were from the supplements. They immediately began to reduce inflammation and reduce brain fog and ear ringing. The Tirzepatide reduced my appetite a great deal but more importantly stopped all the craving “food noise” that drove my eating addiction. I often found myself still going to lunch as if I were hungry out of routine but then couldn’t eat anything.  Without doing any exercise weight began to drop at a steady rate of about 8-10 lbs. per month. I began walking more and working out after losing 75 lbs. because I felt so good that wanted to keep the weight loss trend going. The hormone pellets were a more subtle improvement to my overall health that contributed to reducing inflammation but also helped me maintain my muscle mass during weight loss. So far, I have lost 120 pounds and I’m working on 70 more by Labor Day 2025.  I look forward to the data continuing to trend in the right direction as I watch my muscle mass increase as my weight decreases.  

Q: How has this journey impacted your life?

Amy: I’m healthier, happier, and more confident. It’s why I started Defy of Indiana—to help others experience this transformation. There is nothing more rewarding than helping people feel like themselves again.

Mitch: This journey saved my life. I feel confident, energized, more productive. Most importantly, I now believe I’ll live long enough to see my kids grow up and start families of their own.

Q: What is your advice for someone considering this journey?

Amy: YOU are worth it. Don’t settle for feeling tired or stuck. Take the first step—it can profoundly change your life.

Mitch: Commit to the evaluation and stick with it for six months. You’ll see results in half that time and feel better than ever. You won’t regret it.

Ready to Transform Your Life? 

Your health isn’t just about numbers—it’s about how you feel and live every day. At Defy of Indiana, we’re here to help you regain control, energy, and confidence. If Amy and Mitch’s stories of wellness resonate with you, it’s time to take the first step. Schedule your consultation today by calling 317-361-4481 or visiting our website at defyofindiana.com and filling out our contact form. Start your journey toward feeling your absolute best. YOU deserve it!